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Once they lost in Switzerland the Republic of Irelands hopes of qualifying for Euro 2020 rest on next months home game with Denmark.
Victory would have booked the Irishs location but Haris Seferovic and Edimilson Fernandes reach the aims.
A win over the Danes on 18 November will fasten qualification from Group D.
However, the Irish will be at conceding a penalty saved by Darren Randolph without captain Seamus Coleman, who had been sent .
After Tuesdays match had been jeopardized by rain, Switzerlands first-half stride afforded Fernandes hammered despite the efforts to keep the shot of Shane Duffy from the second in the final seconds and Benfica striker Seferovics 16th-minute target.
With the Republic changing to some more familiar 4-4-2 from their formation, they made second-half strain but the company that was held to put themselves back after their defeat in Copenhagen on Saturday.
The Republic top Group D goal difference from Denmark with Switzerland a point behind but equally Danes and Swiss have games in hand, which come from out-of-contention sides Gibraltar and Georgia respectively on 15 November.
With improbable slips by the Korean against Georgia and at their final match in Gibraltar – or Denmark losing to Gibraltar – a Republic win against the Danes in their match will probably be enough to secure qualification for McCarthys side.
If the Swiss only select up four points in their two matches, the Irish would have to win by 2 targets.
They may have the fallback choice of a location, if that route fails.
McCarthy handed a first start after his encouraging cameo in Saturdays uninspiring draw in Georgia to Brighton youngster Aaron Connolly but rather it had been the Breel Embolo who was the offender in the first half that was pivotal of Borussia Monchengladbach.
With Embolo finding space all too easily, he helped the Swiss split out a string of first-half chances and Seferovics finish through Shane Duffys legs from.
Following the first half had been commanded by the Swiss of the Republic rallied but beyond having a Glenn Whelan shot blocked, had little to reveal in the way of clearcut opportunities.
Colemans dismissal came after he had been adjudged to have managed an Embolo shot from the 76th minute, which followed his first-half yellow card with Arsenals Granit Xhaka for an exchange.
Replacement Ricardo Rodriguezs spot-kick was superbly saved by randolph while Fabian Schar headed before Fernandes objective against the Republic woodwork in the second half.
The Republics screen in Saturdays 0-0 draw in Georgia came in for criticism and McCarthy opted for three changes in addition to the modified formation.
As Callum Robinson dropped out, together with Preston midfielder Alan Browne carrying more than Conor 24, brighton youngster Connolly partnered James Collins in attack.
Sheffield Uniteds Enda Stevens returned set up of Matt Doherty after suspension but has been part of a three-man defence alongside John Egan and Shane Duffy as expected.
Regardless of Saturdays 1-0 defeat by Denmark, Swiss boss Vladimir Petkovic chosen to get an unchanged starting line-up and his faith was rewarded because the home side took control.
The signs were ominous for the visitors as Xhaka analyzed Randolph in the seventh minute before player of this year Seferovic blasted reduced through the legs of Duffy to the internet from just outside the box after Jeff Hendrick header.
In Ray keeper Yann Sommer, a Glenn Whelan corner was led by Duffy right In the other end before the break but it was a Republic goal effort.
After hammering his three at the back formation midway during the first half, McCarthy introduced Callum ODowda to get striker Collins at half-time also it assisted the visitors produce some pressure in the next quarter.
Nevertheless, the Swiss were continuing to carve with Randolph having to tilt more than a header and then seeing Schars header come back off a post.
Connolly was substituted by Scott Hogan on 70 minutes before Colemans dismissal after conceding the punishment because he picked up a second yellow card.
The Randolph stretched to his left to keep out Rodriguezs spot-kick but can do nothing like Fernandes blasted in despite Duffys efforts in the last moment of injury-time.
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